Introduction: The current study aimed to compare the quality of ROOT CANAL obturation performed with cold lateral condensation with other obturation techniques. Materials and Methods: Diverse Search was conducted using six electronic/academic databases following PICOS (i. e. population, intervention, control, outcomes, and study design) strategy: (P) Extracted mature permanent teeth,(I) Obturation techniques except for cold lateral condensation,(C) Cold lateral condensation tyechnique,(O) Quality of ROOT CANAL obturation,and (S) In vitro studies assessing parameters using micro-computed tomography. The statistical method used for the meta-analyses was the “inverse variance DerSimonian-Laird test”. The heterogeneity data was calculated using the T2, Cochran Q test, and I2 statistics. Results: Fifteen studies were included for the final analysis,one had a low risk of bias, eight a moderate risk, and six a high risk of bias. Ten studies were selected for meta-analyses,three studies comparing cold lateral condensation with carrier-based gutta-percha techniques [P=0. 96,mean difference (MD)=-0. 02,confidence interval (CI): (-0. 77, 0. 73),I2=21%],three comparing cold lateral condensation with single-cone techniques [P=0. 75,MD=-0. 39,CI: (-2. 77, 1. 99),I2=92%],two comparing cold lateral condensation and thermo-plasticized injectable techniques [P=0. 37,MD=5. 91,CI: (-7. 13, 18. 94),I2=99%],and five comparing cold lateral condensation with warm vertical condensation techniques [P<0. 0001,MD=5. 29,CI=(2. 84, 7. 74),I2=92%]. The overall effect reported significant results [P=0. 0003,MD=2. 69,CI=(1. 23, 4. 16),I2=96%],favoring fewer voids and gaps for the other used obturation techniques. Conclusions: Cold lateral condensation and single-cone techniques presented no statistical differences. Nonetheless, Warm vertical condensation technique had better results compared to cold lateral condensation.